Monoamine oxidase - Wikipedia
Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. [1] [2] They are found bound to the outer membrane of mitochondria in most cell types of the body. The first such enzyme was discovered in 1928 by Mary Bernheim in the liver and was named ...
Monoamine oxidase A - Wikipedia
Monoamine oxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene. [5] [6] This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin.
Structures and Mechanism of the Monoamine Oxidase Family
Monoamine oxidase (MAO) family members oxidize a variety of amine substrates, including small-molecule monoamines and polyamines and modified amino acids within proteins.
Monoamine Oxidase - an overview | ScienceDirect Topics
Monoamine oxidase is the enzyme principally responsible for degradation of amine neurotransmitters (norepinephrine, epinephrine, serotonin, and dopamine). There are two isoenzymes of monoamine oxidase: monoamine oxidase A (MAO-A) and MAO-B. MAO-A preferentially deaminates serotonin, norepinephrine, and epinephrine as well as dietary ...
单胺氧化酶 - 维基百科，自由的百科全书
单胺氧化酶 （缩写MAO）， EC 1.4.3.4，是 催化 单胺 类物质 氧化 脱氨反应 的 酶。 单胺氧化酶存在于 细胞 的 线粒体 外膜 上，在人体内分布极广，尤以 肝 、 脑 及 肾 等组织细胞内的含量最高。 由于需要 黄素腺嘌呤二核苷酸 （FAD）作 辅因子，因此它属于 黄素蛋白 或 含黄素胺氧化酶 家族。 1928年 玛丽·伯恩海姆 在肝细胞中首先发现单胺氧化酶，并将其命名为“ 酪胺 氧化酶 ”。 [1] 人体内含有两种单胺氧化酶： 单胺氧化酶A （MAO-A）和 单胺氧化酶B （MAO-B）。 两者 …
MONOAMINE OXIDASE: From Genes to Behavior - PMC
Monoamine oxidase (MAO) (monoamine; oxygen oxidoreductase, deaminating, EC 1.4.3.4) catalyzes the oxidative deamination of a number of biogenic amines in the brain and peripheral tissues by the production of hydrogen peroxide (H 2 O 2) (Shih 1991, Thorpe et al 1987).
Monoamine Oxidase - an overview | ScienceDirect Topics
Monoamine oxidase (MAO) is a mitochondrial-bound enzyme with high expression levels in neuronal and gastro-intestinal tissues. The enzyme exists in two isoforms: MAO-A and MAO-B. These isoforms demonstrate significant sequence similarity but differ in their substrate-inhibitor recognition sites and tissue distribution.
Monoamine Oxidases - PubMed
Monoamine oxidases A and B (MAO A and B) are mammalian flavoenzymes bound to the outer mitochondrial membrane. They were discovered almost a century ago and they have been the subject of many biochemical, structural and pharmacological investigations due to their central role in neurotransmitter met …
Monoamine oxidase inactivation: from pathophysiology to …
Monoamine oxidases (MAOs) A and B are mitochondrial bound isoenzymes which catalyze the oxidative deamination of dietary amines and monoamine neurotransmitters, such as serotonin, norepinephrine, dopamine, β-phenylethylamine and other trace amines.
Kinetics, mechanism, and inhibition of monoamine oxidase
Monoamine oxidases (MAOs) catalyse the oxidation of neurotransmitter amines and a wide variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs.