Cutting Edge: Role of MASP-3 in the Physiological Activation
2019年9月15日 · In the alternative pathway, a factor D (FD) plays essential roles in both the initiation and the amplification loop and circulates as an active form. Mannose-binding lectin-associated serine proteases (MASPs) are key enzymes of the lectin pathway, and MASP-1 and/or MASP-3 are reported to be involved in the activation of FD.
Cutting Edge: Role of MASP-3 in the Physiological Activation of …
2019年9月15日 · In the alternative pathway, a factor D (FD) plays essential roles in both the initiation and the amplification loop and circulates as an active form. Mannose-binding lectin–associated serine proteases (MASPs) are key enzymes of the lectin pathway, and MASP-1 and/or MASP-3 are reported to be involved in the activation of FD.
OMS906, a Novel Alternative Pathway MASP-3 Inhibitor, …
2023年11月2日 · Proximal and alternative pathway (AP) inhibition block both IVH and EVH, as demonstrated with C3, Factor B, and Factor D inhibitors. Mannan-binding lectin-associated serine protease-3 (MASP-3) activates pro-Factor D, thus activating the AP upstream of Factor D. OMS906 is a highly selective humanized mAb that binds to and inhibits MASP-3.
MASP-3 is the exclusive pro-factor D activator in resting blood: …
We demonstrated that in resting blood, the alternative pathway strictly relies on the presence of an extraneous proteinase, which is a component of the lectin pathway. Our discovery questions whether the alternative pathway can be rightfully considered as an …
Frontiers | The complex formation of MASP-3 with pattern …
2022年8月15日 · We have previously reported that mannose-binding lectin-associated serine protease (MASP)-3, unlike its splicing variant MASP-1, circulates in an active form and is essential for the activation of the alternative pathway (AP) via …
Therapeutic targeting of factor D and MASP3 in …
2024年6月22日 · Roles of factor D (FD) and MASP3 in alternative pathway complement activation. MASP3 catalyzes the conversion of pro-FD to fully functional mature FD by cleaving a 5 amino acid propeptide at the N-terminus. FD cleaves factor B (FB) bound to C3b, thereby creating the C3 convertase C3bBb, which is stabilized by properdin (P).
MASP-3 is the exclusive pro-factor D activator in resting ... - PubMed
2016年8月18日 · For this study we evolved a specific MASP-3 inhibitor and unambiguously proved that activated MASP-3 is the exclusive pro-FD activator in resting blood, which demonstrates a fundamental link between the lectin and alternative pathways.
P787: ALTERNATIVE PATHWAY MASP-3 INHIBITOR OMS906: …
OMS906 is a humanized monoclonal antibody that binds to and inhibits MASP-3. Preclinical data demonstrate the therapeutic potential of OMS906 to inhibit AP activity. As an upstream inhibitor, OMS906 is predicted to block intravascular hemolysis and, unlike C5 inhibitors, to prevent extravascular hemolysis in PNH.
MASP3 deficiency in mice reduces but does not abrogate alternative …
2023年5月5日 · The result showed reduced CP activity in Masp3 −/− mice (Masp3KO), likely reflecting impaired amplification by the alternative pathway. Panels a-d all used 10% plasma from wildtype (WT), Masp3 −/− (Masp3KO), C5 knockout (C5KO), C4 knockout (C4KO), factor B knockout (fBKO) and C3 knockout (C3KO) mice.
pathway activation. 1,2 • OMS906 is a humanized IgG4 mAb that binds to and inhibits MASP-3, thereby blocking maturation of CFD and downstream alternative pathway activity. 3,4 ‒Data from mice and monkeys demonstrated that OMS906 is highly selective for MASP-3 and effectively inhibits alternative pathway activity. 3