Cardiac glycoside - Wikipedia
Cardiac glycosides have long served as the main medical treatment to congestive heart failure and cardiac arrhythmia, due to their effects of increasing the force of muscle contraction while reducing heart rate.
Cardiac Glycosides: What Are They - Osmosis
2020年11月24日 · How do cardiac glycosides work? The mechanism of action of cardiac glycosides involves inhibiting the Na + K + ATPase enzyme, also known as the sodium-potassium pump.
Cellular mechanism of action of cardiac glycosides | Journal of …
It has long been known that cardiac glycosides can inhibit the membrane sodium-potassium (Na +-K +) pump, raising intracellular Na +. However, at clinical concentrations of cardiac glycosides, a change in intracellular Na + that correlates with a change in cardiac
A review of cardiac glycosides: Structure, toxicokinetics, clinical ...
2019年2月1日 · Cardiac glycosides bind and inhibit the sodium and potassium pump affecting the heart. Digoxin, ouabain, oleandrin and bufalin are the most well known cardiac glycosides. Recent findings report additional mechanisms of action and also contribute to the diagnosis of poisoning.
Cellular mechanism of action of cardiac glycosides
1985年5月1日 · Mechanism of Contraction The normal sequence of contraction in a cardiac cell can be divided into three components: 1) the action potential that triggers release of Ca2+ into the cytoplasm, 2) the sarcoplasmic reticulum that stores Ca2 + in the cell, and 3) the contractile proteins that use Ca2+ and adenosine triphosphate (ATP) to generate force.
Cardiac Glycosides - SpringerLink
Cardiac glycosides (CG) are potent and highly specific inhibitors of the intrinsic plasma membrane Na + /K + ‐ATPase, also known as the sodium pump. They modulate electrophysiological properties of the heart and its contractile functions.
Cardiac Glycosides - SpringerLink
2020年5月23日 · Cardiac glycosides act in the cardiac muscle cells to inhibit the activity of Na + /K +-ATPase, which is an entropy-driven reversible reaction (Fig. 2). This enzyme is a P-type pump that physiologically maintains low levels of intracellular Na +, by actively transporting Na + outside and K + into cells in a 2:3 stoichiometry.
Cellular mechanism of action of cardiac glycosides - PubMed
It has long been known that cardiac glycosides can inhibit the membrane sodium-potassium (Na+-K+) pump, raising intracellular Na+. However, at clinical concentrations of cardiac glycosides, a change in intracellular Na+ that correlates with a change in …
The molecular mechanism of cardiac glycoside action
1972年5月1日 · Cardiac glycosides increase cardiac muscle contractility (positive inotropic effect) by playing a role in the coupling of electrical excitation with mechanical contraction. There is currently some difference of opinion about the over-all …
Endogenous and Exogenous Cardiac Glycosides and their Mechanisms of Action
2012年8月17日 · Cardiac glycosides have been used for decades to treat congestive heart failure. The recent identification of cardiotonic steroids such as ouabain, digoxin, marinobufagenin, and telocinobufagin in blood plasma, adrenal glands, and hypothalamus of mammals led to exciting new perspectives in the pathology of heart failure and arterial hypertension.