N-Methylpiperazine - Wikipedia
N-Methylpiperazine is a heterocyclic organic compound. N -Methylpiperazine is a common building block used in organic synthesis. [2] . For example, N -methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine, [3] meclizine, and sildenafil.
1-Methylpiperazine | C5H12N2 | CID 53167 - PubChem
1-Methylpiperazine | C5H12N2 | CID 53167 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1-Methylpiperazine 99 109-01-3 - MilliporeSigma
1-Methylpiperazine is a heterocyclic diamine used as a versatile building block and intermediate in organic synthesis. [1] [2] [3] 1-Methylpiperazine was used as mimic template in the preparation of molecularly imprinted microspheres (MIMs) [4].
N-甲基哌嗪 CAS#: 109-01-3 - ChemicalBook
2024年12月8日 · 主要用作氧氟沙星、氯氮平、西地那非、吐立抗、佐匹克隆等药物的中间体，亦可用于农药、染料、塑料等行业。 有机合成、制药、合成纤维等的中间体。 由六水哌嗪经甲基化反应而得。 将六水哌嗪及盐酸加入反应锅中，加热至45℃，滴加甲酸和甲醛的混合液。 加毕，在50℃左右反应2-3h，再升温回流，至二氧化碳气体不再逸出为止。 冷却至80℃，加入盐酸，加热蒸酸至干。 稍冷后加入甲醇，加热回流30min，趁热过滤（滤渣为哌嗪二盐酸盐）。 滤液回 …
N-甲基哌嗪_化工百科 - ChemBK
主要用作氧氟沙星、氯氮平、西地那非、吐立抗、佐匹克隆等药物的中间体，亦可用于农药、染料、塑料等行业。 0.903g/mLat 25°C (lit.) 138°C (lit.) n20/D 1.466 (lit.) 无色液体。 沸点138℃（140℃），相对密度0.903（20/4℃），折光率1.4378，闪点42℃，溶于水、乙醚、乙醇，与水、甲醇等任意比互溶，在水溶液中呈弱碱性。 R10 - 易燃。 R21 - 与皮肤接触有害。 R23 - 吸入有毒。 R34 - 引起灼伤。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R20/21 - 吸入及皮肤 …
N-甲基哌嗪 - 百度百科
合成硝呋哌酮（又名呋喃哌嗪酰胺,Nifurpipone）、 三氟拉嗪 等数十种药物。 用于制取抗菌类药物甲哌 利福霉素 、抗精神病药三氟拉嗪及氧氟沙星等 ,主要用作氧氟沙星、氯氮平、 西地那非 、吐立抗、佐匹克隆等药物的中间体，亦可用于农药、染料、塑料等行业。 由六水哌嗪经 甲基化反应 而得。 将六水哌嗪及盐酸加入反应锅中，加热至45℃，滴加甲酸和甲醛的混合液。 加毕，在50℃左右反应2-3h，再升温回流，至 二氧化碳 气体不再逸出为止。 冷却至80℃，加入盐酸， …
1-Methylpiperazine CAS 109-01-3 | 805859 - Merck
1-Methylpiperazine for synthesis. CAS 109-01-3, pH 11 - 12 (50 g/l, H₂O, 20 °C). H226: Flammable liquid and vapour. H314: Causes severe skin burns and eye damage. H317: May cause an allergic skin reaction. H332: Harmful if inhaled. P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
1-Methylpiperazine | 109-01-3 - ChemicalBook
2024年12月18日 · 1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene.
Piperazine, 1-methyl- - NIST Chemistry WebBook
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Piperazine, 1-methyl- - NIST Chemistry WebBook
Quantity Value Units Method Reference Comment; T boil: 411.2: K: N/A: Weast and Grasselli, 1989: BS: T boil: 410.65: K: N/A: Lanum and Morris, 1969: Uncertainty ...