Mitochondrial TCA cycle metabolites control physiology and …
2020年1月3日 · Recent studies indicate a fifth mechanism whereby mitochondria release TCA (tricarboxylic acid) cycle metabolites to control cell fate and function (Fig. 2). TCA cycle metabolites were...
Mitochondrial TCA cycle metabolites control physiology and …
Recent evidence confers a new role for TCA cycle intermediates, generally thought to be important for biosynthetic purposes, as signaling molecules with functions controlling chromatin modifications, DNA methylation, the hypoxic response, and immunity.
Nuclear localization of mitochondrial TCA cycle enzymes …
2022年12月2日 · Our results reveal an important role of mitochondrial TCA cycle enzymes in the epigenetic regulation of pluripotency that constitutes a mitochondria-to-nucleus retrograde signaling mode in ...
TCA cycle and mitochondrial membrane potential are necessary …
Mitochondrial metabolism is necessary for the maintenance of oxidative TCA cycle function and mitochondrial membrane potential. Previous attempts to decipher whether mitochondria are necessary for biological outcomes have been hampered by genetic and pharmacologic methods that simultaneously disrupt multiple functions linked to mitochondrial ...
Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of …
In the eukaryotic system, the TCA cycle occurs completely in mitochondria, while the intermediates of the TCA cycle are retained inside mitochondria due to their polarity and hydrophilicity. Under cell stress conditions, mitochondria can become disrupted and release their contents, which act as danger signals in the cytosol.
Mitochondrial TCA cycle metabolites control physiology and disease
2020年1月3日 · This review summarizes the mechanisms by which the abundance of different TCA cycle metabolites controls cellular function and fate in different contexts. We will focus on how these metabolites mediated signaling can affect physiology and disease.
TCA Cycle and Mitochondrial Membrane Potential Are Necessary …
2016年1月21日 · Here, we report that inducible depletion of mitochondrial DNA (ρ ο cells) diminished respiration, oxidative TCA cycle function, and the mitochondrial membrane potential, resulting in diminished cell proliferation, hypoxic activation of HIF-1, and specific histone acetylation marks.
Regulation of the mitochondrial tricarboxylic acid cycle
2013年6月1日 · The tricarboxylic acid (TCA) cycle is composed by a set of eight enzymes primarily linking the product of the oxidation of pyruvate and malate (generated in the cytosol) to CO 2 with the generation of NADH for the oxidation by the mitochondrial respiratory chain [8].
Recent studies indicate a fth mechanism whereby fi mitochondria release TCA (tricarboxylic acid) cycle metabolites to control cell fate and function (Fig. 2). TCA cycle metabolites were...
Regulation and function of the mammalian tricarboxylic acid cycle
2023年2月1日 · Mitochondrial Ca 2+ uptake primarily occurs via the mitochondrial calcium uniporter, a highly selective ion channel in the inner mitochondrial membrane. Mitochondrial calcium uniporter–mediated Ca 2+ influx is driven by …