Neuronal Death - an overview | ScienceDirect Topics
Neuronal death refers to the natural process of cell death in neurons during normal nervous system development, influenced by interactions with trophic substances and hormones to ensure proper neural connections and tissue remodeling.
Neuronal Cell Death - PubMed
2018年4月1日 · We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic cell death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, and mitochondrial permeability transition.
Neuronal Cell Death - an overview | ScienceDirect Topics
Neuronal cell death refers to the natural process of the orderly ontogeny of the nervous system, where approximately half of all neurons born ultimately die during development. It can also occur in the adult as a result of experimental intervention or injury that interferes with neuronal-target interactions and the consequent supply of trophic ...
Neuronal Cell Death: Neuron
Neuronal cell death can occur abnormally by its timing, its causes, or its extent. In many cases, changes in the normal pattern of neuronal death are reflected in impaired survival or altered behavior.
Neuronal cell death in neurodegenerative diseases: recurring …
This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases.
Neuronal Cell Death Mechanisms in Major Neurodegenerative …
Neuronal cell death is one of the major pathological hallmarks of neurodegenerative diseases. Several primary regions of the brain suffer neuronal loss, while as diseases progress, these regions can be expanded in some conditions.
A Perspective on Neuronal Cell Death Signaling and …
During development, programmed cell death via apoptosis assures that appropriate matches exist between neurons and their target cells. Nuclear changes are late events and the first steps leading toward developmental neuronal death typically occur in …
Neuronal cell death in nervous system development, disease
Neuronal death is normal during nervous system development but is abnormal in brain and spinal cord disease and injury. Apoptosis and necrosis are types of cell death. They are generally considered to be distinct forms of cell death. The re-emergence of apoptosis may contribute to the neuronal degen …
Mechanisms of Neural Cell Death: Implications for Development …
Neuronal loss occurs as an essential feature of normal CNS development, as well as in acute or chronic neurodegenerative disorders. 1 – 4 It has long been recognized that a variety of factors can trigger secondary auto-destructive reactions within the CNS, including free radicals, excitatory amino acids, eicosanoids, lipid degradation ...
Molecular mechanisms of cell death in neurological diseases
2021年6月7日 · While removal of superfluous neuronal cells is vital for normal brain function, aberrant death of distinct neuronal cell populations is a hallmark of pathology associated with...
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