The neutron beam radiotherapy is powerful, specialized and highly effective form of external beam radiotherapy that can control the large tumours because unlike low Linear Energy Transfer (LET) radiation, it does not depend upon the presence of oxygen to kill the malignant cells.
A MCNP6 dosimetry model is presented for the Clinical Neutron Therapy System (CNTS) at the University of Washington. In the CNTS, fast neutrons are generated by a 50.5 MeV proton beam incident on a 10.5mm thick Be target. The production, …
Exploiting the unique interaction characteristics of fast neutrons …
2024年3月1日 · Overall, fast neutron therapy holds potential for the treatment of certain tumors by leveraging the unique interaction characteristics of fast neutrons with biological tissues. This review therefore intends to bring this uniqueness to light to enhance the understanding of the radiobiological properties of fast neutrons and the advantages ...
Efficient optimization of an accelerator neutron source for neutron ...
2024年5月12日 · Design and optimize BSA more efficiently to achieve neutron beams that meet specified recommendations. We propose an approach of NSGA II with crucial variables which are identified by multivariate statistical techniques. This approach significantly reduces the problem sizes, thus reducing the time required for optimization.
Microdosimetric Modeling of Biological Effectiveness for Boron Neutron …
2018年1月17日 · Neutron capture therapy using the 10 B (n, α) 7 Li reaction, BNCT, is one of the most effective therapeutic modalities for treating locally invasive malignant tumors thanks to the large...
Neutron flux evaluation model provided in the accelerator
2021年4月13日 · An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient neutron flux for treatment although the neutron flux is reduced...
Neutron flux evaluation model provided in the accelerator-based …
2021年4月13日 · An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient neutron flux for treatment although the neutron flux is reduced over the lifetime of its target.
Geant4 beam model for boron neutron capture therapy
2018年1月23日 · Boron neutron capture therapy (BNCT) is a biochemically-targeted type of radiotherapy, selectively delivering localized dose to tumour cells diffused in normal tissue, while minimizing normal tissue toxicity.
Mechanistic Modeling of the Relative Biological Effectiveness of Boron ...
2020年10月15日 · In this paper, we present a computational, multiscale system of models to better assess the relative biological effectiveness (RBE) and compound biological effectiveness (CBE) of several neutron sources as applied to BNCT using boronophenylalanine (BPA) and a potential monoclonal antibody (mAb) that targets HER-2-positive cells with Trastuzumab.
Mechanistic Modeling of the Relative Biological Effectiveness of Boron ...
2020年10月15日 · In this paper, we present a computational, multiscale system of models to better assess the relative biological effectiveness (RBE) and compound biological effectiveness (CBE) of several...