Nilotinib | C28H22F3N7O | CID 644241 - PubChem
Nilotinib is a member of (trifluoromethyl)benzenes, a member of pyrimidines, a member of pyridines, a member of imidazoles, a secondary amino compound and a secondary carboxamide. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor and an anticoronaviral agent.
Nilotinib - Wikipedia
Nilotinib, sold under the brand name Tasigna among others, is a anti-cancer medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. [3] [7] It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib. [3] [7] [8] It is ...
Crystal Structure of Nilotinib Hydrochloride Monohydrate …
2024年4月30日 · The crystal structure of nilotinib hydrochloride monohydrate, being an active pharmaceutical substance of the drug Tasigna for chronic myeloid leukemia, is determined by powder X-ray diffraction (XRD) using a synchrotron radiation source of the National Research Center “Kurchatov Institute”.
Crystal structure of nilotinib, C28H22F3N7O | Powder …
2015年8月14日 · The crystal structure of nilotinib has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques.
Chemical structure of nilotinib | Download Scientific Diagram
Nilotinib was subjected to acid and alkali hydrolysis, oxidation, thermal, and photo-degradation. The degradation products were well separated from the pure drug. The method was based on...
Nilotinib | C28H22F3N7O - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for Nilotinib, 641571-10-0, Tasigna, HHZIURLSWUIHRB-UHFFFAOYSA-N
Crystal structure of nilotinib, C28H22F3N7O | Request PDF
2015年8月14日 · The crystal structure of nilotinib has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques.
Chemical structure of Nilotinib | Download Scientific Diagram
Nilotinib is a tyrosine kinase inhibitor used for the treatment of chronic myelogenous leukemia. A stability indicating liquid chromatographic method (Isocratic mode) was developed and validated...
Crystal structure of nilotinib, C28H22F3N7O - NASA/ADS
The crystal structure of nilotinib has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques. Nilotinib crystallizes in space groupP1 (#1) witha= 4.518 14(3),b= 10.638 01(5),c= 13.703 77(8) Å,α= 68.8607(4),β= 82.1486(5),γ= 84.1978(5)°,V= 607.62(1) Å3, andZ= 1.
Nilotinib: a Novel, Selective Tyrosine Kinase Inhibitor - PMC
2009年9月21日 · Nilotinib, a second-generation oral TKI, was rationally designed based on the crystal structure of imatinib to be highly active against a wide range of imatinib-resistant BCR-ABL mutants and is approved for the treatment of newly diagnosed or imatinib-resistant or -intolerant CML, and has shown superiority over imatinib in first-line in newly ...