Senescence and aging: the critical roles of p53 | Oncogene - Nature
2013年2月18日 · Mechanistically, senescence relies on two main molecular pathways: p53–p21 (discussed later) and p16 INK4A-Rb. p16, a cyclin/cdk inhibitor, prevents phosphorylation of Rb by cyclin/cdk...
Role of p53 in the Regulation of Cellular Senescence
2020年3月8日 · The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity.
p53 and p16 INK4A independent induction of senescence by
2011年9月13日 · Altogether, these results show that inhibition of p300 HAT is able to induce a p53/p21 CIP1 - and p16 INK4A-independent senescence-like growth arrest in normal and cancer cell lines.
p53 dependence of senescence markers p21v1 and p21v2 in …
2 天之前 · We also observed that MEF cells passaged to senescence upregulated p16, p21, p21v2 and p53, but not p21v1, unlike that in the H 2 O 2-treated cells (Fig. 2l–p, Supplementary Fig. S2).
Expression of p16 and p53 in non-small-cell lung cancer ...
p16 and p53 are frequently altered intracellular pathways in cancers. We investigated the aberrant expression of p16 and its relationship with p53 and HPV status in primary non-small-cell lung carcinoma. Patients & methods: Lung tumor tissue microarray (n = 163), immunohistochemical study of p16 and p53, and HPV in-situ hybridization were analyzed.
WT1, p53 and p16 expression in the diagnosis of low- and high …
2018年3月3日 · The IHC p53/p16 index aims to differentiate between LGSOC and HGSOC using p53 and p16 IHC in WT1-positive samples. LGSOCs are characterized by the focal expression of both p53 and p16, whereas HGSOCs are defined as tumours with diffuse p53 expression or complete absence of p53 expression (null type) associated with diffuse p16 expression.
Reversal of human cellular senescence: roles of the p53 and p16 ...
2003年8月15日 · Our results indicate that the senescence response to telomere dysfunction is reversible and is maintained primarily by p53. However, p16 provides a dominant second barrier to the unlimited growth of human cells.
Role of p53 in the Regulation of Cellular Senescence - MDPI
2020年3月8日 · The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity.
The Role of p53/p21/p16 in DNA-Damage Signaling and DNA Repair
2016年1月1日 · The tumor-suppressor proteins p53, p21, and p16 are major regulators of the G1/S cell–cycle checkpoint. Upon p53 stabilization, the transcription of p21 is induced, subsequently resulting in the inhibition of CDK4/6–cyclin D and CDK2–cyclin E complexes by p21.
P16 and p53 play distinct roles in different subtypes of
2013年10月11日 · The p16 (INK4a) and p53 pathways are two of the major pathways involved in control of the cell cycle. They also play key roles in tumorigenesis. However, whether the roles of these pathways differ in the subtypes of breast cancer is unclear.
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