p53: emerging roles in stem cells, development and beyond
2018年4月13日 · However, recent advances, such as the genomic profiling of embryonic stem cells, have uncovered the significance and mechanisms of p53 functions in mammalian cell differentiation and development. As we review here, these recent findings reveal roles that complement the well-established roles for p53 in tumor suppression.
The Role of the p53 Protein in Stem-Cell Biology and Epigenetic ...
The p53 protein plays a passive and an active role in stem cells. The transcriptional activities of p53 for cell-cycle arrest and DNA repair are largely turned off in stem cells, but there is some indication that long-term stem-cell viability may require other p53-regulated functions.
p53: A tale of complexity and context - Cell Press
2024年3月28日 · We know now that p53 can orchestrate a plethora of biological processes and cell states, including multiple key metabolic pathways, different DNA repair processes, stem cell modulation, aging, development, fertility, and still others.
Functions of p53 in pluripotent stem cells - PubMed
In response to DNA damage or oncogenic stress, p53 plays multiple roles in maintaining genomic stability of somatic cells by inducing cell cycle arrest, apoptosis, and senescence to prevent the passage of genetic mutations to the daughter cells. p53 is also required to maintain the genomic stability of PSCs.
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
2018年6月11日 · CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in human pluripotent cells. CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome...
The Role of the p53 Protein in Stem-Cell Biology and Epigenetic ...
2016年9月1日 · The p53 protein plays a passive and an active role in stem cells. The transcriptional activities of p53 for cell-cycle arrest and DNA repair are largely turned off in stem cells, but there is some indication that long-term stem-cell viability may require other p53-regulated functions.
Critical Role for P53 in Regulating the Cell Cycle of Ground State ...
2020年2月11日 · Compared with somatic cells, mouse embryonic stem cells (ESCs) grown in serum-rich conditions display a shortened G1 phase and lack activity of the P53-P21 pathway. Stunnenberg and colleagues show that P53 is activated upon adaptation of ESCs to their pluripotent ground state in serum-free conditions.
p53 in stem cells - PMC - National Center for Biotechnology …
2011年9月9日 · A: In mammary gland stem cells, p53 promotes asymmetric cell division, resulting in an increased number of differentiated cells and a reduction in the stem cell pool; B: In mesenchymal stem cells (MSCs), p53 suppresses proliferation and self-renewal and reduces differentiation by suppressing runx2, osterix and pparγ; C: p53 supports quiescence ...
p53 switches off pluripotency on differentiation | Stem Cell …
2016年9月22日 · The new discoveries of p53 family proteins in pluripotent stem cells have made possible stable progress in stem cell transplantation efficiency and safety, as well as treatment strategies targeting cancer stem cells based on pluripotent stem cell technology.
p53, Stem Cells, and Reprogramming - PMC - National Center for ...
p53 (the product of the human TP53 and mouse TRP53 genes) is best known and most extensively studied as a pivotal signaling node that converts diverse upstream stress signals into downstream responses including cell cycle arrest, senescence, DNA repair, and …