Pathology Outlines - Paget disease
2021年9月20日 · Most mammary Paget disease (MPD) is an extension of ductal carcinoma in situ (DCIS) from the underlying ducts, not LCIS. Paget cells have no known specific recurring genetic alterations and are genetically similar to the underlying breast carcinoma cells in most cases.
Pathology Outlines - Paget disease
2024年4月2日 · Paget disease is intraepithelial adenocarcinoma primarily involving the epidermis of vulvar skin, with or without an underlying invasive adenocarcinoma Menu Chapters By Subspecialty
Pathology Outlines - Extramammary Paget disease
2024年9月19日 · Even though sebaceous carcinoma is positive for EMA and keratin, the presented histology with PAS positivity is not consistent with this diagnosis. A 73 year old man presents to his primary care physician with a pruritic, well demarcated erythematous plaque on …
Paget's Disease - Pathology - Orthobullets
2023年12月24日 · Paget's Disease is an idiopathic condition of abnormal bone remodeling with normal bone being replaced through an active interplay between excessive bone resorption and abnormal new bone formation. The condition typically present in patients age > 40 with asymptomatic lesions discovered incidentally on radiographs.
Pathobiology of Paget's Disease of Bone - PMC - PubMed Central …
Paget's disease of bone is a late-onset skeletal disease affecting 2-5% of Caucasians over 55 years old that is characterized by highly localized areas of increased bone resorption accompanied by exuberant, but aberrant, new bone formation that results in bony expansion and structural weakness of the involved bone.
Paget’s Disease of Bone - Endotext - NCBI Bookshelf
2020年1月4日 · Bone histology revealed increased osteoclastic activity and increased bone formation but the overall histology was not typical of Paget’s disease. A model to explain the coupling of bone resorption to bone formation in Paget’s disease has been developed utilizing osteoclasts from pagetic patients and transgenic mice harboring a knock-in of ...
Epidemiology and pathology of Paget’s disease of bone – a review
Paget’s disease of bone (PDB) is a noninflammatory, metabolic, skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased osteoblastic activity leading to unstructured, fibroblastic, and biomechanically unstable bone.
The Pathology of Paget’s Disease - SpringerLink
Paget’s disease is a common affliction in Western society, being pathologically manifest in approximately 4% of older whites.1 Although rarely fatal, the disorder may be extremely disabling and painful and lead to marked skeletal distortion.
Mammary and extramammary Paget's disease - Journal of Clinical Pathology
This article provides an overview of mammary and extramammary Paget's disease and discusses recent evidence regarding the cell of origin. The concepts of primary and secondary Paget's disease are presented and the differential diagnosis is discussed with reference to immunohistochemical markers that might be of diagnostic value.
Paget disease of the breast | Radiology Case - Radiopaedia.org
Histology: Core biopsy fragments of breast tissue show scattered foci of high-grade ductal carcinoma in situ (DCIS). This is accompanied by a minimal degree of comedonecrosis and coarse calcifications. The DCIS occupies around 25% of the specimen. ... In Paget disease, malignant ductal epithelial cells (ductal carcinoma in situ ...