Hepatic Manifestations in Hematological Disorders - PMC
HPS can cause hepatomegaly, jaundice with cholestasis, moderate transaminase elevation, hyperferritinemia, decreased hepatic synthetic function, and fulminant hepatic failure. Hepatotoxicity is caused by hemophagocytosis in the hepatic sinusoids and portal tracts or by focal hepatocellular necrosis [ 132 ].
Hepatic Manifestations in Hematological Disorders
2013年3月31日 · HPS can cause hepatomegaly, jaundice with cholestasis, moderate transaminase elevation, hyperferritinemia, decreased hepatic synthetic function, and fulminant hepatic failure. Hepatotoxicity is caused by hemophagocytosis in the hepatic sinusoids and portal tracts or by focal hepatocellular necrosis [ 132 ].
Pancytopenia, Hepatomegaly, and Neurologic Abnormalities in …
2023年10月1日 · The finding of pancytopenia results in transfer to our institution after initiating antibiotics for presumed sepsis. The mother reports that the patient was developmentally appropriate until 6 months of age, after which she noted milestone regression.
Cirrhosis With Splenomegaly and Pancytopenia Complicating a …
We report the case of a 63-year-old male with a history of liver cirrhosis from non-alcoholic fatty liver disease who presented for consultation due to pancytopenia without signs of fever or lymphadenopathy. Imaging revealed cirrhosis, ascites, and moderate splenomegaly while the workup for toxins, infections, and HIV was negative.
Approach to pancytopenia: From blood tests to the bedside
2024年9月1日 · Rare but life-threatening causes of pancytopenia include haemophagocytosis syndromes, acute promyelocytic leukaemia causing disseminated intravascular coagulopathy, and paroxysmal nocturnal haemoglobinuria. Blood film and reticulocyte count should be done as part of the initial workup once pancytopenia is confirmed.
Clinical and Etiological Profiles of Patients With Pancytopenia in a ...
On physical examination, all patients with pancytopenia included in our study exhibited pallor, with almost half of them exhibiting splenomegaly; a few exhibiting hepatomegaly, sternal tenderness, pigmentation, and lymphadenopathy; and the other few …
Pancytopenia: a clinico hematological study - PubMed
It is a striking feature of many serious and life-threatening illnesses, ranging from simple drug-induced bone marrow hypoplasia, megaloblastic anemia to fatal bone marrow aplasias and leukemias. The severity of pancytopenia and the underlying pathology determine the management and prognosis.
Pancytopenia, Hepatomegaly, and Neurologic Abnormalities in …
2023年10月1日 · Pancytopenia, Hepatomegaly, and Neurologic Abnormalities in Two Pediatric Patients. Pancytopenia, Hepatomegaly, and Neurologic Abnormalities in Two Pediatric Patients Pediatr Rev. 2023 Oct 1;44(S1):S29-S34. doi: 10.1542/pir.2020-001016. Authors Olufunke Y ...
Pancytopenia, Hepatomegaly, and Neurologic Abnormalities in …
2023年10月1日 · Pancytopenia, Hepatomegaly, and Neurologic Abnormalities in Two Pediatric Patients. A broad clinical and imaging spectrum of heterotopic malformations is revealed and a framework for their classification is provided.
As our patient’s pancytopenia and liver failure worsened, hematophagocytic lymphohistiocytosis (HLH) rose to the top of the differential diagnosis. HLH is a syndrome of excessive immune activation of lymphocytes and macrophages, which then …