Hexaconazole exposure ravages biosynthesis pathway of steroid …
The fungicide hexaconazole was docked with different enzymes involved in the biosynthesis pathway of steroid hormones by AutoDock program version 4.2 (Morris et al., 1998). To avoid the hindrance of the ionic property of water molecules in interaction efficiency each enzyme was optimized by removing crystallographic water molecules.
Efficient analysis of the toxicity and mechanisms of Hexaconazole …
2024年10月23日 · Hexaconazole, Propiconazole, and Prothioconazole are widely used triazole fungicides primarily employed in agriculture for the control of plant diseases, aiming to enhance crop yield and...
Identification of potential chemical biomarkers of hexaconazole …
2024年6月1日 · Hexaconazole [(RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol] (HEX) is a widely used broad-spectrum systemic azole fungicide which is employed to eradicate and prevent fungal diseases in plants (David et al., 2008; Wang et al., 2005). Hexaconazole has been registered for foliar application in crops such as cereals, vegetables ...
Hexaconazole - an overview | ScienceDirect Topics
2010年4月1日 · Hexaconazole (HX) (Fig. 1 D), a triazole fungicide, is typically applied as a foliar spray to control several diseases in cereal, vegetable, and fruit crops. HX consists of a pair of enantiomers, (+)-hexaconazole [(+)-HX] and (−)-hexaconazole [(−)-HX].
Efficient analysis of the toxicity and mechanisms of Hexaconazole …
2024年10月8日 · Pathway analysis highlights key insights into the molecular mechanisms of brain and liver injury induced by triazole fungicides. The significant enrichment of targets in cancer-related pathways suggests that exposure to these fungicides may promote carcinogenic processes in these organs, raising concerns about long-term health effects [54].
Potency of Hexaconazole to Disrupt Endocrine Function with Sex …
2023年2月15日 · In this study, we evaluated the efficacy of hexaconazole to bind with SHBG by molecular interaction, a molecular dynamics method. In addition, principal component analysis was performed to understand the dynamical behaviour of hexaconazole with SHBG in comparison with dihydrotestosterone and aminoglutethimide.
Efficient analysis of the toxicity and mechanisms of Hexaconazole …
Objective: This research aims to elucidate the potential toxic targets and underlying molecular mechanisms of brain and liver damage induced by exposure to the three fungicides through network toxicology combined with molecular docking and bioinformatics data analysis.
Preparation and characterization of hexaconazole/hydroxypropyl …
2024年3月5日 · Hexaconazole (HEZ) is a triazole fungicide with low water solubility, which restricts its use in agricultural production. In this work, HEZ/hydroxypropyl-γ-cyclodextrin inclusion complex nanofibers (HEZ/HPγCD-IC-NF) were successfully …
hexaconazole (CHEBI:81766) - EMBL-EBI
Hexaconazole is a broad-spectrum systemic triazole fungicide used for the control of many fungi particularly Ascomycetes and Basidiomycetes. Major consumption is in Asian countries and it is used mainly for the control of rice sheath blight in China, India, Vietnam, and parts of East Asia.
Hexaconazole induces developmental toxicities via apoptosis ...
Furthermore, hexaconazole treatment altered the Akt and MAPK signaling pathways, which possibly triggered the organ defects and other toxic mechanisms. This study demonstrated the developmental toxicity of hexaconazole to zebrafish and elucidated the underlying mechanisms.