PDGFRβ expression in tumor stroma of pancreatic ... - PubMed
Here, we investigate 26 cases of pancreatic ductal adenocarcinoma and examine the clinicopathological association between survival and expression levels of several molecular markers for stromal cells. These include alpha-smooth muscle actin (SMA) and platelet-derived growth factor (PDGF) receptor β (PDGFRβ).
Clinical functional proteomics of intercellular signalling in ...
2024年11月13日 · The stroma region was stained by IHC targeting PDGFRB, a marker of stroma cells. The PCC region was stained by IHC targeting KRT19, a marker of epithelial cells.
Expression of PDGFRB in cancer - The Human Protein Atlas
Expression of PDGFRB (CD140b, JTK12, PDGFR, PDGFR1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Targeting the PDGF/PDGFR signaling pathway for cancer
2022年3月31日 · In pancreatic cancer cells, PDGF-BB can activate Notch-1 and induce Notch-1/Furin interaction, which upregulates MMP-9 and vascular endothelial growth factor (VEGF) expression, stimulating cell invasion and metastasis [32].
PDGFRβ targeted innovative imaging probe for pancreatic …
2023年4月1日 · Innovative Near-Infrared PDGFRβ-targeting probes were constructed for the detection of pancreatic adenocarcinoma. YQGX-10-MPA exhibited high T/NT values in BxPC-3 tumor bearing mice and an excellent specificity for tumor recognition in …
血小板衍生生长因子受体β（PDGFRB）基因 | MCE
与受体单体结合的生长因子的特性决定了功能性受体是同二聚体 (PDGFB 或 PDGFD) 还是异二聚体 (PDGFA 和 PDGFB) 。 该基因对于心血管系统的正常发育至关重要，并有助于肌动蛋白细胞骨架的重排。 该基因在 5 号染色体上的两侧是粒细胞-巨噬细胞集落刺激因子和巨噬细胞集落刺激因子受体的基因；所有三个基因都可能与 5-q 综合征有关。 5 号和 12 号染色体之间的易位将该基因与 ETV6 基因融合，导致伴有嗜酸性粒细胞增多的慢性骨髓增生性疾病。 [RefSeq 提 …
PDGFRβ + perivascular progenitor cells in tumours regulate
2005年8月21日 · Here we report the identification of tumour-derived PDGFR β+ (platelet-derived growth factor receptor β) progenitor perivascular cells (PPCs) that have the ability to differentiate into pericytes...
Here, we investigate 26 cases of pancreatic ductal adenocarci-noma and examine the clinicopathological association between survival and expression levels of several molec-ular markers for stromal cells. These include alpha-smooth muscle actin (SMA) and platelet-derived growth factor (PDGF) receptor b (PDGFRb).
Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous ...
Missense mutations in the p53 tumor suppressor promote metastasis through poorly understood gain-of-function activities. In pancreatic cancer, mutant p53 disrupts p73/NF-Y signaling, enhancing PDGFRb expression, which drives metastasis formation.
PDGF signalling controls age-dependent proliferation in pancreatic …
Here we show that platelet-derived growth factor receptor (Pdgfr) signalling controls age-dependent β-cell proliferation in mouse and human pancreatic islets. With age, declining β-cell Pdgfr levels were accompanied by reductions in β-cell enhancer of zeste homologue 2 (Ezh2) levels and β-cell replication.