Fumarase - Wikipedia
Fumarase (or fumarate hydratase) is an enzyme (EC 4.2.1.2) that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs cycle and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate ...
5UPP: Crystal structure of human fumarate hydratase - RCSB PDB
2017年2月3日 · Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase. Fumarate hydratases (FHs, fumarases) catalyze the reversible conversion of fumarate into l-malate. FHs are distributed over all organisms and play important roles in energy production, DNA repair and as tumor suppressors.
a crucial function for fumarate hydratase (FH) in bone marrow-derived macrophages (BMDMs). Pharmacological inhibition or genetic ablation of FH led to increased fumarate levels and
Fumarate hydratase as a metabolic regulator of immunity
2024年6月1日 · Fumarate hydratase (FH) and fumarate are now known to regulate cytokine production. Recent findings suggest FH loss leads to mitochondrial nucleic acid release, leading to type I interferon production. Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling pathways in immune cells.
Fumarate hydratase is a critical metabolic regulator of …
2017年3月3日 · Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic hematopoiesis.
Crystal structure of human fumarate hydratase
2018年2月7日 · Primary publication: Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase. Ajalla Aleixo MA , Rangel VL , Rustiguel JK , de Pádua RAP , Nonato MC
Fumarate Hydratase - flipper.diff.org
2009年6月11日 · Fumarase (or fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of Fumarate to S-malate. Two classes of fumarases are described: • class I: Fumarase enzyme catalyses the reversible hydration of fumarate to L-malate. This class comprises thermolabile dimeric enzymes
Fumarate Hydratase - SpringerLink
Fumarate hydratase is an enzyme that functions in the mitochondrial citric acid cycle, catalyzing the reversible hydration/dehydration reaction in which fumarate is converted to malate. The human gene encoding fumarate hydratase is located in the chromosome segment 1q42.3-q43. It consists of ten exons that span over 20 kb of genomic DNA.
Fumarate hydratase: a new checkpoint of metabolic regulation in ...
2023年9月4日 · In a very recent study, we confirmed the upregulation of Alox5 in pro-inflammatory MΦs, revealing a new and unique role for Alox5 in producing leukotriene B4 (LTB4) as a driver of ferroptotic...
Fumarate hydratase catalyzes the stereospecific hydration across the olefinic double bond in fumarate leading to L-malate. The enzyme is expressed in mito-chondrial and cytosolic compartments, and participates in the Krebs cycle in mitochondria, as well as in regulation of cytosolic fumarate levels.