Selenocysteine - Wikipedia
Selenocysteine (symbol Sec or U, [4] in older publications also as Se-Cys) [5] is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur.
硒代半胱氨酸 - 百度百科
硒代半胱氨酸（三字母Sec，单字母U），是一种氨基酸，化学式为C 3 H 7 NO 2 Se。存在于少数一些酶中，如谷胱甘肽过氧化酶、甲状腺素5'-脱碘酶、硫氧还蛋白还原酶、甲酸脱氢酶、甘氨酸还原酶和一些氢化酶等。
Selenocysteine - an overview | ScienceDirect Topics
Selenocysteine (Sec) is the naturally-occurring 21st proteinogenic amino acid. Sec is an analog of cysteine (Cys) with selenium in the place of sulfur. Proteins that contain Sec are named selenoproteins. Humans have 25 known selenoproteins.
Selenocysteine - an overview | ScienceDirect Topics
Selenocysteine is a noncanonical amino acid employed in catalytic sites of specialized oxidoreductase enzymes, known as selenoproteins. It is encoded by UGA, normally a stop codon, which is co-translationally recoded for selenocysteine insertion by dedicated molecular machinery.
The selenocysteine toolbox: A guide to studying the 21st amino acid
2022年11月15日 · Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally similar to cysteine (Cys) but with a sulfur to selenium replacement. This small change confers Sec with related chemical properties to Cys but often with enhanced reactivity.
Biosynthesis of Selenocysteine, the 21st Amino Acid in the …
The biosynthetic pathway for selenocysteine (Sec), the 21st amino acid in the genetic code whose codeword is UGA, was recently determined in eukaryotes and archaea. Sec tRNA, designated tRNA[Ser]Sec, is initially aminoacylated with serine by ...
Biosynthesis, Engineering, and Delivery of Selenoproteins - MDPI
2023年12月22日 · Selenocysteine (Sec) was discovered as the 21st genetically encoded amino acid. In nature, site-directed incorporation of Sec into proteins requires specialized biosynthesis and recoding machinery that evolved distinctly in bacteria compared to archaea and eukaryotes.
Selenocysteine: Synthesis, Function, and Evolution of the 21st Amino Acid
2023年10月31日 · A potential target of precision nutrition in cancer therapeutics is the micronutrient selenium (Se). Se is metabolized and incorporated as the amino acid selenocysteine (Sec) into 25 human selenoproteins, including glutathione peroxidases (GPXs) and thioredoxin reductases (TXNRDs), among others.
Rare, but essential – the amino acid selenocysteine - Research …
2017年6月19日 · Selenocysteine (Sec) is an essential amino acid component in selenoproteins, which are involved in a variety of cellular and metabolic processes. Increasingly, their deregulation is being associated with neurodegenerative and other diseases, for which the underlying mechanisms have remained unclear.
Selenocysteine Biosynthesis, Selenoproteins, and …
2009年10月30日 · Selenocysteine (Sec), the 21st amino acid in the genetic code, is encoded by UGA. The pathway of Sec biosynthesis in eukaryotes has only recently been discovered. Sec is constructed on its tRNA that is initially aminoacylated with serine and modified to a phosphoseryl-tRNA intermediate with the help of several dedicated enzymes.