Role of sclerostin in bone and cartilage and its potential as a ...
Sclerostin is a small protein expressed by the SOST gene in osteocytes, bone cells that respond to mechanical stress applied to the skeleton and appear to play an important role in the regulation of bone remodeling. When sclerostin binds to its receptors on the cell surface of osteoblasts, a downstream cascade of intracellular signaling is ...
Role and mechanism of action of Sclerostin in bone - PMC
It is now clear that sclerostin is capable of uncoupling bone formation and bone resorption, by inhibiting osteoblast function while stimulating osteoclast function, as the bone gain achieved by pharmacologic inhibition of sclerostin results from stimulation of osteoblast activity and inhibition of bone resorption.
Role and mechanism of action of sclerostin in bone - PubMed
In this review, we highlight the current knowledge on the regulation of Sost/sclerotin expression and its mechanism(s) of action, discuss novel observations regarding its role in signaling pathways activated by hormones and mechanical stimuli in bone, and propose future research needed to understand the full potential of therapeutic ...
Sclerostin - Wikipedia
Sclerostin, the product of the SOST gene, located on chromosome 17q12–q21 in humans, [9] was originally believed to be a non-classical bone morphogenetic protein (BMP) antagonist. [10] More recently, sclerostin has been identified as binding to LRP5 / 6 receptors and inhibiting the Wnt signaling pathway .
Role and mechanism of action of sclerostin in bone
Mar 1, 2017 · Sclerostin is a key molecular coordinator of both bone formation and bone resorption. Sclerostin’s skeletal actions are mediated by binding to LRP4 chaperone and LRP5/6 co-receptors and inhibition of Wnt/βcatenin signaling. Sost/sclerostin expression is tightly controlled by transcriptional regulation and epigenetic modifications.
Sclerostin: From Molecule to Clinical Biomarker - PMC
Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt signaling.
The Role of Sclerostin in Bone Diseases - MDPI
Feb 2, 2022 · Sclerostin exhibits a key role in skeletal homeostasis by inhibiting bone formation and promoting bone resorption. Pharmacologic inhibition of sclerostin enhances bone formation and shows positive outcomes in osteoporosis treatment.
Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone ...
Mar 3, 2004 · Sclerosteosis, a skeletal disorder characterized by high bone mass due to increased osteoblast activity, is caused by loss of the SOST gene product, sclerostin. The localization in bone and the mechanism of action of sclerostin are not yet known, but it has been hypothesized that it may act as a bone morphogenetic protein (BMP) antagonist.
Regulation of sclerostin by the SIRT1 stabilization pathway in ...
Feb 15, 2022 · Sclerostin is a key osteocyte-derived factor that suppresses bone formation and promotes bone resorption, therefore regulators of sclerostin secretion are a likely source of new therapeutic...
Sclerostin: From Molecule to Clinical Biomarker - MDPI
Apr 26, 2022 · Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt signaling.