Rebuilding and rebooting immunity with stem cells - Cell Press
2024年4月8日 · Immune regeneration therapies present exciting strategies to address age-related diseases by rebooting the host’s primary lymphoid tissues or rebuilding the immune system directly via biomaterials or artificial tissue. Here, we identify important, unanswered questions regarding the safety and feasibility of these therapies.
Mesenchymal stem/stromal cells (MSCs): origin, immune ... - Nature
2023年5月24日 · Mesenchymal stem/stromal cells (MSCs) are of the most responsive cell populations to inflammation in tissues. MSCs are a kind of tissue stem cells that were initially...
Immunological considerations and challenges for regenerative …
2021年6月25日 · Here we describe the role of the host innate and adaptive immune responses as triggers of allogeneic graft rejection. We discuss how the immune response is determined by the cellular therapy.
Immune modulation by mesenchymal stem cells - PubMed
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent and self-renewal abilities. The characteristics of presenting no major ethical concerns, having low immunogenicity and possessing immune modulation functions make MSCs promising candidates for stem cell therapie …
Two to tango: dialogue between immunity and stem cells in …
Immune cells have surfaced as prominent members of stem cell niches across the body. Here, we draw parallels between different stem cell niches to explore the context-specific interactions that stem cells have with tissue resident and recruited immune cells.
Immunogenicity of Pluripotent Stem Cells and Their Derivatives
2013年2月1日 · Simplified schema exemplifying an immune response to a stem cell–derived cellular therapeutic. Dendritic cells acquire antigens from the graft for presentation to T cells and natural killer (NK) cells, which mount specific responses after …
Reciprocal regulation of mesenchymal stem cells and immune …
2022年11月3日 · At inflamed tissue sites, MSCs can restore the immune homeostasis through directly affecting innate and adaptive immune cells such as macrophages, natural killer (NK) cells, dendritic cells (DCs), mast cells, myeloid-derived suppressor cells, T lymphocytes, and B lymphocytes, and thus blocking the cascade activity of immune responses (Han et al ...
Synthetic immune checkpoint engagers protect HLA-deficient ... - Cell …
2023年11月2日 · Engineering of hypoimmune cells may greatly improve their therapeutic benefit. We present a new class of agonistic immune checkpoint engagers that protect human leukocyte antigen (HLA)-depleted induced pluripotent stem cell …
Understanding Stem Cell Immunogenicity in Therapeutic Applications
2015年12月10日 · Here, we review the current understanding of the mechanisms of immune recognition associated with stem cell immunogenicity, and discuss the relevance of reprogramming and differentiation strategies used to generate cells or tissue from stem cells for implantation in eliciting an immune response.
Advances in mesenchymal stem cell therapy for immune and …
Broad immunomodulatory properties of human tissue and pluripotent stem cell‐derived mesenchymal stem cells (MSCs), as well as MSC‐derived products toward multiple types of immune cells allow for therapeutic use toward a spectrum of immune and inflammatory disorders.