T cell anergy - PubMed
T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen encounter, but remains alive for an extended period of time in a hyporesponsive state. Models of T cell anergy affecting both …
T cell anergy, exhaustion, senescence, and stemness in the …
Recent studies have started to reveal the nature of effector T cells in the tumor microenvironment. In this article we discuss T cell anergy, exhaustion, senescence, and stemness, and review the phenotype of dysfunctional T cell subsets and the underlying molecular mechanisms in the tumor microenvironments.
T cell anergy, exhaustion, senescence and stemness in the tumor ...
T cell activation relies on the T cell receptor (TCR) recognizing its cognate antigen in the context of MHC molecules from an antigen presenting cell (APC) or an APC-like cell (tumor cell). Interaction between co-stimulatory molecules CD80, and CD86 and CD28 is crucial for appropriate T cell activation.
Molecular regulation of T-cell anergy - PMC - PubMed Central …
T-cell anergy is thought to represent one mechanism of peripheral tolerance that maintains T cells in an ‘off' state when full immune activation is not desirable, such as in response to self-antigens.
Molecular mechanisms of CD4 + T-cell anergy - Nature
2007年7月6日 · Understanding the state of long-lived functional unresponsiveness of T cells, known as T-cell anergy, could help to prevent T-cell-driven autoimmune diseases.
T Cell Anergy - Annual Reviews
T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen encounter, but remains alive for an extended period of time in a hyporesponsive state. Models of T cell anergy affecting both CD4+ and CD8+ cells fall into two broad categories.
New Insights into the Molecular Basis of T Cell Anergy: Anergy …
2009年6月15日 · A central hallmark of anergy, as first described in CD4 + Th1 clones, is the failure to synthesize the major T cell growth factor IL-2, resulting in an abortive proliferative response ; but anergy in primary CD4 + and CD8 + T cells is also characterized by defective production of inflammatory cytokines such as IFN-γ and TNF-α .
T-cell anergy - ScienceDirect
2004年4月1日 · Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for …
T cell anergy - PubMed
T cell clonal anergy is a proposed mechanism of immunologic self tolerance in which T cells become functionally inactivated after previous stimulation. MHC class II-restricted antigen presentation by different cell types has been speculated to have a role in determining activation vs. anergy in resp …
Uncovering the mechanisms that regulate tumor-induced T-cell anergy
2013年2月1日 · The immunosuppressive tumor microenvironment induces anergy in helper T cells through the NFAT-dependent expression of anergy-inducing genes, coding for proteins that can inhibit TCR signaling and silence cytokine expression.