Adverse effects of antiepileptic drugs - ScienceDirect
2012年9月1日 · More than 150 years after bromide was introduced as the first antiepileptic drug, adverse effects remain a leading cause of treatment failure and a major determinant of impaired health-related quality of life in people with epilepsy. Adverse effects can develop acutely or many years after starting treatment and can affect any organ or structure.
Specific adverse effects of antiepileptic drugs--A true-to-life ...
Levetiracetam (n=151), lamotrigine (n=167), valproic acid (n=73), or controlled-release carbamazepine (n=47) were the most commonly used antiepileptic drugs (AEDs). Independent predictors for general high AE burden (LAEP score≥45) were duration of epilepsy, lack of 12-month seizure freedom, and partial epilepsy, but none of the four ...
2015年6月26日 · Adverse effects of antiepileptic drugs are roughly divided into acute early idiosyncratic reactions to drugs associated with allergic mechanisms, dose-dependent inhibitory action on the nervous system, and chronic phase adverse effects seen after
Adverse effects of antiepileptic drugs - PubMed
More than 150 years after bromide was introduced as the first antiepileptic drug, adverse effects remain a leading cause of treatment failure and a major determinant of impaired health-related quality of life in people with epilepsy. Adverse effects …
Efficacy, pharmacology, and adverse effects of antiepileptic drugs
2001年5月1日 · Reviewed here are the clinical pharmacology and adverse effects of the commonly used traditional and newer antiepileptic drugs, including their indications for use in treatment for epilepsy (Table 1). Table 1. Guidelines for antiepileptic drug dosing. AED—antiepileptic drug.
Adverse effects of antiepileptic drugs - ScienceDirect
2012年9月1日 · In this Review, we discuss the adverse effect profiles of available antiepileptic drugs, highlight the clinical relevance of these side-effects, and provide practical recommendations for their prevention, assessment, and management.
Efficacy, pharmacology, and adverse effects of antiepileptic drugs
The clinical use of commonly used traditional antiepileptic drugs and the newly marketed antiepileptic drugs is discussed. This includes the specific indications for use, adverse effects, and dosing of each drug. Drug interactions, mechanisms of action, and pharmacological properties of each drug is also reviewed.
Adverse antiepileptic drug effects: Toward a clinically and ...
Adverse effects (AEs) of antiepileptic drugs can be classified in five biologically plausible factors. When specific classes of AEs are identified and attempts are made to reduce them, quality of life is significantly improved. GLOSSARY AE = adverse effect; AED = antiepileptic drug; AEP = Adverse Event Profile; BDI = Beck Depression Inventory; GABA
Adverse effects of antiepileptic drugs - The Lancet Neurology
2012年8月12日 · Several new-generation antiepileptic drugs with improved tolerability profiles and reduced potential for drug interaction have been added to the therapeutic armamentarium. Overall, these advances have expanded the opportunities to tailor treatment with antiepileptic drugs, to enhance effectiveness and minimise the risk of toxic effects.
General side effects and challenges associated with anti-epilepsy ...
Anti-epilepsy medications may cause unwanted side effects in some patients. The common side effects identified by Stephen et al. 14 are feelings of tiredness, stomach upset, dizziness or blurred visions, which