肿瘤中的突变型p53：从分子机制到治疗策略 - 知乎
2022年12月8日 · p53蛋白是一种转录因子，通常分为三个功能区：氨基末端结构域、DNA结合域和羧基末端结构域。 野生型p53(wt p53)通过调控多个靶基因的转录，在许多重要的生物学过程中发挥关键作用。
Recent findings on the role of wild-type and mutant p53 in cancer ...
R175H and R273H are more prone to aggregation than wild-type (WT) p53, and their pathological aggregation can lead to various cancers. A recent study investigated the dynamic and structural properties of the R175H and R273H mutants in the p53 core domain (p53C) using extensive all-atom molecular dynamics simulations.
Upregulation of wild-type p53 by small molecule-induced
2021年5月25日 · Here, we reported that a new quinolone compound RYL-687 significantly inhibited non-small cell lung cancer (NSCLC) cells which express wild type (wt) p53, in contract to its much weaker...
Wild-type p53 in cancer cells: when a guardian turns into a ... - PubMed
2009年1月1日 · The remarkable potency of p53 in suppressing tumorigenic outgrowth has promoted the expectation that tumor cells expressing wild-type p53 (wtp53) should be more prone to elimination by cytotoxic treatments than tumor cells expressing mutant p53 (mutp53) with defunct wtp53 activities.
p53: A tale of complexity and context - Cell Press
2024年3月28日 · However, when bona fide wild-type (WT) p53 was finally tested, it not only failed to elicit oncogenic transformation of cultured cells—it actually potently suppressed transformation driven by classical oncoproteins, including MYC and RAS. Hence, authentic WT p53 behaved as a tumor suppressor, not an oncoprotein .
Understanding wild-type and mutant p53 activities in human
2010年10月22日 · New roles and functions of p53 relevant for tumor suppressions were presented, including the regulation of microRNAs networks, the modulation of cell–stroma interactions and the induction of ...
Frontiers | Targeting mutant p53-R248W reactivates WT p53 …
2023年1月10日 · Several molecules have been reported to restore WT p53 function in tumors that express mutant p53 (24, 25). Of those, three have been shown to be effective against the R248 mutation. MIRA-1 prevents unfolding of both WT-p53 and mut-p53 and restores native WT-p53 conformation in R248Q .
Wt-p53 action in human leukaemia cell lines corresponding to …
Recent studies support the potential application of the wt-p53 gene in cancer therapy. Expression of exogenous wt-p53 suppresses a variety of leukaemia phenotypes by acting on cell survival, proliferation and/or differentiation.
However, when bona fide wild-type (WT) p53 was finally tested, it not only failed to elicit oncogenic transformation of cultured cells—it actually potently suppressed transformation driven by classical onco-proteins, including MYC and RAS. Hence, authentic WT p53 behaved as a tumor suppressor, not an oncoprotein (Figure 1).
A common druggable signature of oncogenic c-Myc, mutant KRAS …
2024年8月31日 · Proteomics and transcriptomics reveal common, targetable pathways driven by mutant p53, mutant KRAS, and c-Myc. To reveal protein and RNA populations controlled by oncogenes – mutant TP53 ...