苯溴马隆 - 百度百科
苯溴马隆是一种 苯并呋喃 中的具有 代表性 的衍生物，具有强力去尿酸的作用，还可以有效地抑制尿酸的生成，对降低 血尿酸 的浓度具有 双重作用，缓解疼痛和 红肿，消除 痛风结石，可用于治疗 原发性 高尿酸血症， 痛风性关节炎 间歇期及痛风结节肿等。 抗痛风药。 [3-6] 原发性高尿酸血症，以及 痛风性关节炎 间歇期。 1、对本品中任何成分过敏者。 2、中至重度肾效用侵害者（肾小球滤过率 低于20mL/min）及患有 肾结石 的患者。 3、孕妇、 妊娠期 妇女以及 哺乳期妇女 禁用 …
Benzbromarone - Wikipedia
Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase [1] used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. It is structurally related to the antiarrhythmic amiodarone. [2]
Benzbromarone in the treatment of gout - Advances in …
2019年8月7日 · Benzbromarone is a uricosuric drug that has been used in the treatment of gout over the last 30 years. Due to its potent inhibition of the dominant apical (luminal) urate exchanger in the human proximal tubule URAT1, it reduces the urate reabsorption, diminishing serum urate levels and therefore preventing gout flares.
BENZBROMARONE的適應症、成分、用法與用量、作用機轉、副 …
benzbromarone的用量、作用機轉、副作用、懷孕及哺乳用藥與藥物交互作用，benzbromarone適應症:痛風、高尿酸血症。
Benzbromarone: Uses, Interactions, Mechanism of Action
2016年10月20日 · Benzbromarone is a uricosuric agent which is taken daily for the prevention of gout flares. Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia.
苯溴马隆片 - 百度百科
药理作用：本品属苯骈呋喃衍生物，为促尿酸排泄药，作用机制主要定通过抑制肾小管对尿酸的重吸收，从而降低血中尿酸浓度。 毒理研究：据报道，大鼠长期口服 [50mg/kg/日 (约为临床用 …
苯溴马隆片详细说明书-注意事项-不良反应-用法用量-39药品通
英文名称：Benzbromarone tablets 汉语拼音：Benxiumalong Pian 【成份】 本品主要成份是苯溴马隆。 【性状】 本品为白色或类白色片。 【适应症】 原发性高尿酸血症，痛风性关节炎间歇期及痛风结节肿等。 【用法用量】
Benzbromarone | C17H12Br2O3 | CID 2333 - PubChem
Benzbromarone is a nonpurine xanthine oxidase inhibitor used for the treatment of gout, but never approved for use in the United States because of concerns over reports of acute liver injury and deaths with its use.
苯溴马隆(Benzbromarone) - 药物靶点：URAT1_在研适应症：高 …
Treatment with benzbromarone, a UA-lowering drug, alleviated renal injury, restored m6A methylation levels, and upregulated METTL14 expression. Cellular experiments showed that METTL14 overexpression attenuated high UA-induced fibrosis in renal tubular epithelial cells.
Benzbromarone: A Review of its Pharmacological Properties and ...
2012年11月3日 · Synopsis: Benzbromarone is a benzofuran derivative which lowers serum urate and increases urinary urate excretion in normal, hyperuricaemic and gouty subjects. In open short- and long-term studies benzbromarone reduced serum uric acid levels by one-third to one-half and maintained its effectiveness for periods of up to 8 years.
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