Deamination - Wikipedia
Enzymes that catalyse this reaction are called deaminases. In the human body, deamination takes place primarily in the liver; however, it can also occur in the kidney. In situations of excess protein intake, deamination is used to break down amino acids for energy. The amino group is removed from the amino acid and converted to ammonia.
Discovery of deaminase functions by structure-based protein …
Jul 20, 2023 · By generating protein classifications based on predicted structures, we have developed a suite of ssDNA deaminases (Sdds) and dsDNA deaminases (Ddds) used for precision genome editing. We highlight that enzyme mining based on structures predicted by AlphaFold2 is a simple, flexible, and high-throughput method to classify and engineer proteins ...
Deaminase - an overview | ScienceDirect Topics
A deaminase is an enzyme that acts on RNA molecules by converting adenosine (A) to inosine (I) in double-stranded RNA. It contains specific domains for binding to RNA and catalyzing the deamination process. You might find these chapters and articles relevant to this topic. J. Scott, in Brenner's Encyclopedia of Genetics (Second Edition), 2001.
Biotechnological applications of purine and pyrimidine deaminases
Deaminases, ubiquitous enzymes found in all living organisms from bacteria to humans, serve diverse and crucial functions. Notably, purine and pyrimidine deaminases, while biologically essential for regulating nucleotide pools, exhibit exceptional versatility in biotechnology.
Evolution of the deaminase fold and multiple origins of eukaryotic ...
Using sensitive sequence and structural comparison methods, we develop a comprehensive natural classification of the deaminase-like fold and show that its ancestral version was likely to operate on nucleotides or nucleic acids.
Structural Biochemistry/Deaminase - Wikibooks
Deaminase is an enzyme that is involved in the process of Deamination in which the process removes an amine group (NH2) from a molecule through hydrolysis. The enzyme will usually only remove an amine group from extra proteins and this occurs in the liver or kidneys.
Deaminase - an overview | ScienceDirect Topics
Deaminases are activated in all cells, mainly by invading pathogens, viruses, bacteria and fungi (Schoggins & Rice, 2011). Thus, they play a pivotal role in the cause of gene mutations coupled to environmental signals.
Nucleobase deaminases: a potential enzyme system for new …
Nucleobase deaminases are essential enzymes that are involved in the catabolic pathway and stringently regulate the concentration of the nucleobase derivative pool, which is paramount for nucleotide recycling. This review presents an overview of the ...
Engineered deaminases as a key component of DNA and RNA …
Over recent years, zinc-dependent deaminases have attracted increasing interest as key components of nucleic acid editing tools that can generate point mutations at specific sites in either DNA or RNA by combining a targeting module (such as a ...
Nucleoside deaminases: the key players in base editing toolkit
Dec 12, 2023 · In this review, we summarize the cytidine and adenosine deaminases that have been widely applied in the base editing field and highlight the structural and functional features of the native enzyme and their engineered variants, which have led to the development of more efficient and precise BEs.