羟喜树碱 - 百度百科
羟喜树碱（Hydroxycamptothecin）为从珙桐科落叶植物喜树的种子或根皮中提出额一种生物碱。 喜树碱因泌尿系统毒性大，临床应用受到限制。 本品为喜树碱的羟基衍生物，作用机制与喜树碱相似，但毒性较小。
10-Hydroxycamptothecin | C20H16N2O5 | CID 97226 - PubChem
10-Hydroxycamptothecin is a pyranoindolizinoquinoline. 10-hydroxycamptothecin is under investigation in clinical trial NCT00956787 (Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)). 10-Hydroxycamptothecin has been reported in Nothapodytes nimmoniana, Fusarium solani, and Camptotheca acuminata with data available. View More...
羟喜树碱(Hydroxycamptothecine) - 药物靶点：TOP1_在研适应 …
We constructed a pH-responsive nanoplatform, which co-carried siRNA and anticancer drug (hydroxycamptothecine, HCPT), to integrate gene therapy and chemotherapy for combination cancer therapy.
10 Hydroxycamptothecin - an overview | ScienceDirect Topics
3.3 10-hydroxycamptothecin-UFAs. Camptothecin (CPT) is a potent antitumoral agent first separated in 1966 from a Chinese tree, named Camptotheca acuminate (Nyssaceae) [155]. Due to its potential and promising anti-tumor effect, CPT and its synthetic analogs, such as 9-nitro-CPT, 10-hydroxy-CPT (HCPT), irinotecan and topotecan, have received ...
10-羟基喜树碱 CAS#: 19685-09-7 - ChemicalBook
10-Hydroxycamptothecin (5-20 nM)显著抑制Colo 205细胞的分化，使细胞周期停滞在G2期，并通过胱天蛋白酶-3-依赖性途径诱导细胞凋亡。 体内研究 在CAM模型中，10-Hydroxycamptothecin治疗浓度依赖性抑制血管生成，在25 nM剂量下抑制95%，比125 nM下仅抑制60%血管生成 …
9-Hydroxycamptothecin | C20H16N2O5 | CID 135403790
9-Hydroxycamptothecin | C20H16N2O5 | CID 135403790 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Advances in Antitumor Nano-Drug Delivery Systems of 10 ...
2022年9月14日 · 10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility …
10-HYDROXYCAMPTOTHECIN
10-Hydroxycamptothecin (10-HCPT), an indole alkaloid isolated from a Chinese tree, Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity in vitro and in vivo.
10-Hydroxycamptothecin | C20H16N2O5 | CID 4330531
(+/-)-10-Hydroxycamptothecin | C20H16N2O5 | CID 4330531 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Hydroxy Camptothecine | 羟基喜树碱 | Topoisomerase 抑制剂
Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.