Single-cell Long Non-coding RNA Landscape of T Cells in …
2021年6月1日 · Here, by systematically analyzing full-length single-cell RNA sequencing (scRNA-seq) data of more than 20,000 libraries of T cells across three cancer types, we provided the first comprehensive catalog and the functional repertoires of lncRNAs in human T cells.
Single-cell Long Non-coding RNA Landscape of T Cells in …
Here, by systematically analyzing full-length single-cell RNA sequencing (scRNA-seq) data of more than 20,000 libraries of T cells across three cancer types, we provided the first comprehensive catalog and the functional repertoires of lncRNAs in human T cells.
Expression and functions of long noncoding RNAs during human T …
2015年4月23日 · These analyses identify numbers of lncRNAs expressed by T cells, identity of lncRNAs exhibiting lineage-specific expression and the underlying mechanisms to achieve lineage-specific lncRNA...
LncRNA Malat1 suppresses pyroptosis and T cell-mediated
2024年1月9日 · Nature Cancer - Kumar et al. show that the lncRNA Malat1 prevents gasdermin D-mediated pyroptosis induction, in turn suppressing inflammatory cell death and mediating immune evasion and...
Long Non-Coding RNA Function in CD4+ T Cells: What We Know …
2019年7月12日 · One example of a functional lncRNA in CD4 + T cell differentiation is seen with the intergenic lncRNA (linc) linc-MAF-4. Linc-MAF-4 was first identified by RNA-seq data analysing human T cell subsets.
RNA circuits and RNA-binding proteins in T cells - ScienceDirect
2023年10月1日 · A novel lncRNA TCLlnc1 promotes peripheral T cell lymphoma progression through acting as a modular scaffold of HNRNPD and YBX1 complexes
Expression and regulation of lincRNAs during T cell development …
Here we identify 1,524 lincRNA clusters in 42 T cell samples from early T cell progenitors to terminally differentiated T helper (T H) subsets. Our analysis revealed highly dynamic and cell-specific expression patterns of lincRNAs during T cell differentiation.
Potential impact and mechanism of Long Non-coding RNAs on …
2021年6月11日 · Lin Zhang et al. demonstrated that knockdown of a novel lncRNA, which is characterized from the Jurkat leukemic T-cell line can induce apoptosis of T-cell acute lymphoblastic leukemia (T-ALL) cells by promoting the formation of par-4 /THAP1 protein complex, thus increasing the activation of caspase-3 and the expression of pro-apoptotic smac ...
Distinct Processing of lncRNAs Contributes to Non ... - Cell Press
2020年4月6日 · Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs. Whether conserved lncRNAs undergo conserved processing, localization, and function remains unexplored. We report differing subcellular localization of lncRNAs in human and mouse embryonic stem cells (ESCs).
Population-scale tissue transcriptomics maps long non ... - Cell Press
2021年4月16日 · To systematically characterize these lncRNA genes, we used Genotype Tissue Expression (GTEx) project v8 genetic and multi-tissue transcriptomic data to profile the expression, genetic regulation, cellular contexts, and trait associations of 14,100 lncRNA genes across 49 tissues for 101 distinct complex genetic traits.