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Within seconds of inhaling cigarette smoke or vape mist, or using chewing tobacco, nicotine causes the release of dopamine in the brain, which gives people a good feeling. Over time, the brain begins to crave that feeling from nicotine and people need to use more and more tobacco to get that same good feeling. And attempts at stopping have caused physical and mood-related symptoms, such as strong cravings, anxiety, irritability, restlessness, difficulty concentrating, depressed mood, frustration
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